It has a lot of sentimental value to me and Karameikos is very close to a Byzantine style realm (if the Eastern Empire was a semi autonomous Duchy ruling over Serbians/Romanians).
A little tweaking moves the collapsing Thyatian Empire to more a mid period Aurian empire collapse rather than the beginning. By moving the breakaway of The Emirates of Ylaruam to something like 100 years ago, and moving up the threat of the Ethenagar Khanate (possibly even having subjugated the Emirates and taken them into forced alliance like the Mongol Khans did for their own expansion) you get the Sycos threat.
Im interested in any additional ways to tweak the alignment between the two settings. Needless to say Galantri is going to get a haircut… no 30th level mages for you!